Advertisement
Brief report| Volume 21, ISSUE 2, P221-224, February 1986

Urinary excretion of free tyramine and of norepinephrine and its metabolites in unipolar depressed patients

  • Alec Roy
    Correspondence
    Address reprint requests to Alec Roy, M.B., Section on Clinical Studies, Clinical Neuroscience Branch, National Institute of Mental Health, Bldg, 10, Rm. 4N214, 9000 Rockville Pike, Washington, D.C. 20205-1000.
    Affiliations
    From the Section on Clinical Studies, Clinical Neuroscience Branch, Washington, D.C. USA

    the National Institute on Alcohol Abuse and Alcoholism, DICBR, Laboratory of Clinical Studies, Washington, D.C.USA
    Search for articles by this author
  • Markku Linnoila
    Affiliations
    the National Institute on Alcohol Abuse and Alcoholism, DICBR, Laboratory of Clinical Studies, Washington, D.C.USA
    Search for articles by this author
  • Farouk Karoum
    Affiliations
    the National Institute on Alcohol Abuse and Alcoholism, DICBR, Laboratory of Clinical Studies, Washington, D.C.USA

    the Adult Psychiatry Branch, NIMH, Washington, D.C. USA
    Search for articles by this author
  • David Pickar
    Affiliations
    the National Institute on Alcohol Abuse and Alcoholism, DICBR, Laboratory of Clinical Studies, Washington, D.C.USA

    From the Section on Clinical Studies, Clinical Neuroscience Branch, Washington, D.C. USA
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • American Psychiatric Association
        3rd ed. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC1980
        • Bonham Carter S
        • Sandier M
        • Goodwin BL
        • Sepping P
        • Bridges PK
        Decreased urinary output of tyramine and its metabolites in depression.
        Br J Psychiatry. 1978; 132: 125-132
        • Bonham Carter SM
        • Reveley MA
        • Sandler M
        • Dewhurst J
        • Little B
        • Hayworth J
        • Priest R
        Decreased urinary output of conjugated tyramine is associated with lifetime vulnerability to depressive illness.
        Psychiatry Res. 1980; 3: 13-21
        • Endicott J
        • Spitzer R
        A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia.
        Arch Gen Psychiatry. 1979; 35: 837-844
        • Hamilton M
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
        • Harrison W
        • Cooper T
        • Stewart J
        • Quitkin F
        • McGrath P
        • Liebowitz M
        • Rabkin J
        • Markowitz J
        • Klein D
        The tyramine challenge test as a marker for melancholia.
        Arch Gen Psychiatry. 1984; 41: 681-692
        • Karoum F
        • Neff N
        Quantitative gas chromatography-mass spectrometry [GC-MS] of biogenie amines: theory and practice.
        in: Spector S Beck N Modern Methods in Pharmacology. Alan R. Liss, New York1982
        • Koslow S
        • Mass J
        • Bowden C
        • Davis JK
        • Hanin I
        • Javaid J
        CSF and urinary biogenic amines and metabolites in depression and mania.
        Arch Gen Psychiatry. 1983; 40: 999-1010
        • Linnoila M
        • Karoum F
        • Potter W
        High positive correlation between urinary free tyramine excretion rate and “whole body” norepinephrine turnover in depressed patients.
        Biol Psychiatry. 1982; 17: 1031-1036
        • Linnoila M
        • Karoum F
        • Miller T
        • Potter W
        Reliability of urinary monoamine and metabolite output measurements in depressed patients.
        Am J Psychiatry. 1983; 140: 1055-1057
        • Roy A
        • Pickar D
        • Linnoila M
        • Potter W
        Plasma norepinephrine in affective disorders: Relationships to melancholia.
        Arch Gen Psychiatry. 1985; (in press).
        • Roy A
        • Linnoila M
        • Karoum F
        • Pickar D
        Relative activity of metabolic pathways for norepinephrine in endogenous depression.
        Acta Psychiatr Scand. 1986; (submitted).
        • Roy A
        • Pickar D
        • Douillet P
        • Karoum F
        • Linnoila M
        Urinary monoamines and monamine metabolites in subtypes of unipolar depressive disorder and normal controls.
        Psychol Med. 1986; (submitted).
        • Sandier M
        • Bonham Carter S
        • Cuthbert MF
        • Pare C
        Is there an increase in monoamine oxidase activity in depressive illness?.
        Lancet. 1975; i: 1045-1049