This paper is only available as a PDF. To read, Please Download here.
Abstract
Some reports have indicated a neurotoxic interaction of haloperidol and lithium, whereas
others have not found this interaction. This is a report on two patients who showed
both photomyoclonic and photoparoxysmal responses while on combined lithium-haloperidol
treatment. We suggest that these findings, which have not been previously reported
to be associated with combined lithium-haloperidol treatment, reflect neurotoxicity
and that electroencephalogram (EEG) monitoring should be done on patients receiving
this combined medication regimen.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- EEG observations during combined lithium and neuroleptic treatment.Am J Psychiatry. 1979; 136: 336-337
- Adverse reactions in treatment with lithium carbonate and haloperidol.JAMA. 1976; 236: 2645-2646
- Lithium carbonate, haloperidol and irreversible brain damage.JAMA. 1974; 230: 1283-1287
- Electroencephalographic effects of lithium.in: Johnson SN Lithium Research and Therapy. Academic Press, London1975
- Persisting neurologic sequelae of lithium carbonate therapy.Arch Neurol. 1983; 40: 747-751
- Lithium effect on human electroencephalogram.Clinical Electroencephalog. 1971; 2: 89-102
- Paroxysmal discharges induced by intermittent light stimulation.EEG Clin Neurophysiol. 1982; 35 (Suppl): 333-344
- Neurotoxicity with combined use of lithium and thioridazine.J Clin Psychiatry. 1979; 40: 135-138
- EEG observations in confirming neurotoxicity (letter to the editor).Am J Psychiatry. 1979; 136: 1099-1100
- New data on lithium and haloperidol incompatibility.Am J Psychiatry. 1981; 136: 818-821
- Effects of lithium carbonate on memory and other cognitive functions.Am J Psychiatry. 1980; 137: 1042-1046
- Activation methods.in: Niedemeyer E Lopes DA Silva F Electroencephalography; Basic Principles, Clinical Applications and Related Fields. Urban and Schwarzenberg, Baltimore1982: 179-195
- La maladie de lafora.Rev EEG Neurophysiol. 1978; 8: 107-122
- Cognitive changes in acute schizophrenia with brief neuroleptic treatment.Am J Psychiatry. 1981; 138: 1307-1310
Article info
Publication history
Received in revised form:
July 26,
1985
Received:
April 12,
1985
Identification
Copyright
© 1986 Published by Elsevier Inc.