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Abstract
Ninety-one schizophrenics (mean age 34 years) were examined for tardive dyskinesia
(TD) during chronic neuroleptic treatment. Dyskinesia was found in 23 (25.3%). The
only variable that showed an association with TD was the current doses of neuroleptics:
in none of the TD patients did the dose of fluphenazine decanoate (or equivalent)
exceed 45 mg/week, whereas it was higher in 23 of the 68 without TD (p< 0.01). When these 23 “high-dose” patients were disregarded, the TD group differed
significantly from the 45 dose-matched non-TD subjects in that it had more common
anticholinergic drugs, more common parkinsonian symptoms, and less instances of good
remission (p < 0.05 in each case). There was no association between TD and other considered variables
(drug history, age, sex, clinical characteristics, size of the lateral brain ventricles,
neurological “soft” signs, cognitive impairment). The results illustrate a relationship
between TD prevalence and current doses of neuroleptics and indicate that differences
in doses between the groups with and without TD may obscure associations between dyskinesia
and other factors.
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Article info
Publication history
Received in revised form:
August 22,
1985
Received:
March 26,
1985
Footnotes
☆Supported in part by grants from the Wellcome Trust, the Medical Research Council, and the Oxford Regional Research Fund.
Identification
Copyright
© 1986 Published by Elsevier Inc.
