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Abstract
Adrenocorticotrophic hormone (ACTH) and other biosynthetically related peptides are
found both in the brain and peripherally, but the function and regulation of these
substances differ in the brain and in the periphery. It has been suggested that measurement
of peptide hormones in the cerebrospinal fluid (CSF) might provide information relevant
to the diagnosis and pathophysiology of neurological and psychiatric illnesses. We
report experiments using a rhesus monkey model to evaluate parameters affecting CSF
ACTH concentrations. We found that (1) CSF ACTH concentrations follow a diurnal rhythm
that is markedly different from that in plasma, (2) concentrations of ACTH in monkey
CSF, but not in plasma, increased significantly after 4 days of social separation,
and (3) CSF ACTH concentrations did not change after hypophysectomy. These results
suggest that CSF ACTH concentrations reflect the activity of brain and not peripheral
ACTH systems.
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Article info
Publication history
Received in revised form:
August 26,
1985
Received:
May 29,
1985
Footnotes
☆Recipient of 1985 A.E. Bennett Award for Basic Science.
☆☆Supported in part by the Veterans Administration and by NIH Grant NS-19867.
Identification
Copyright
© 1986 Published by Elsevier Inc.
