This paper is only available as a PDF. To read, Please Download here.
Abstract
Density of 3H-imipramine binding sites and serotonin (5-HT) uptake in blood platelets
were repeatedly recorded in normal controls (![Math Eq]()
) and depressed patients (![Math Eq]()
for the imipramine binding assay and![Math Eq]()
for the serotonin uptake) over a 1-year period. The study demonstrated a striking
seasonal variation of both parameters in both groups, with lower values in winter
and spring than in summer and fall. No difference in the density of 3H-imipramine
binding sites was found between the two populations throughout the year, but serotonin
uptake was significantly decreased in depressed patients in May and September. These
results underscore the importance of studying controls and patients at the same time
of the year.
) and depressed patients (
for the imipramine binding assay and
for the serotonin uptake) over a 1-year period. The study demonstrated a striking
seasonal variation of both parameters in both groups, with lower values in winter
and spring than in summer and fall. No difference in the density of 3H-imipramine
binding sites was found between the two populations throughout the year, but serotonin
uptake was significantly decreased in depressed patients in May and September. These
results underscore the importance of studying controls and patients at the same time
of the year.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Reduced uptake of serotonin but unchanged 3H-imipramine binding in the platelets from cirrhotic patients.Life Sci. 1981; 29: 2323-2329
- A modified assay method for determining serotonin uptake in human platelets.Clin Chim Acta. 1981; 122: 225-233
- Seasonal variation of serotonin uptake in normal controls and depressed patients.Biol Psychiatry. 1984; 19: 795-804
- Decreased 3H-imipramine binding in depressed males and females.Commun Psychopharmacol. 1981; 4: 425-432
- 3H-imipramine platelet binding sites in unipolar depression.Biol Psychiatry. 1983; 18: 1403-1409
- Platelet 3H-imipramine binding in euthymic bipolar patients.Psychiatry Res. 1982; 9: 215-219
- Human platelets possess high-affinity binding sites for 3H-imipramine.Eur J Pharmacol. 1979; 58: 347-348
- Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients.Science. 1980; 209: 303-305
- Seasonal variation in the apparent number of binding sites for 3H-opioids agonists and antagonists.Life Sci. 1981; 28: 2577-2583
- Platelet 5-hydroxytryptamine accumulation in depressive illness.Clin Chim Acta. 1978; 87: 165-168
- Inhibition of 5-hydroxytryptamine reuptake by amitryptyline and zimelidine and its relationship to their therapeutic action.Psychopharmacology. 1979; 63: 125-129
- Lithium restores abnormal 5-HT transport in patients with affective disorders.Br J Psychiatry. 1980; 136: 235-238
- Blood noradrenaline and 5-HT levels in depressed women during amitryptyline or lithium treatment.Psychopharmacology. 1982; 77: 236-241
- Seasonal patterns of suicide, depression and electroconvulsive therapy.Br J Psychiatry. 1976; 129: 472-475
- Psychiatric disorder, hospital admission and season.Arch Gen Psychiatry. 1978; 35: 769-771
- Circannual variations in the density of tritiated imipramine binding sites on blood platelets in man.Neuropsychobiology. 1983; 10: 101-102
- 3H-imipramine binding sites in platelets of hospitalized psychiatric patients.Psychiatry Res. 1985; 14: 177-187
- A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
- 3H-Desipramine and 3H-imipramine binding are not associated with noradrenaline and serotonin uptake in the brain.Eur J Pharmacol. 1981; 78: 491-493
- High-affinity 3H-imipramine binding in rat hypothalamus: Association with uptake of serotonin but not of norepinephrine.Science. 1980; 210: 1133-1135
- Tritiated imipramine binding distinguishes among subtypes of depression.Arch Gen Psychiatry. 1985; 42: 485-488
- 3H-imipramine binding sites in platelets from psychiatric patients.Psychiatry Res. 1982; 7: 221-227
- Serotonin uptake in blood platelets of psychiatric patients.Arch Gen Psychiatry. 1981; 38: 1322-1326
- Serotonin uptake in blood platelets and the Dexamethasone Suppression Test in depressed patients.Psychiatry Res. 1983; 8: 41-47
- Effect of lithium carbonate on serotonin uptake in blood platelets of patients with affective disorders.J Affect Disord. 1983; 5: 215-221
- Regional distribution of 3H-imipramine binding in rat brain.Brain Res. 1981; 210: 493-498
- Demonstration of specific high-affinity binding sites for 3H-imipramine on human platelets.Life Sci. 1980; 26: 953-959
- Does high-affinity 3H-imipramine binding label serotonin reuptake sites in brain and platelet?.Life Sci. 1981; 28: 2753-2760
- Depressed patients have decreased binding of tritiated imipramine to platelet serotonin transporter.Arch Gen Psychiatry. 1981; 38: 1315-1317
- A simplification of the protein assay method of Lowry et al. which is more generally applicable.Anal Biochem. 1977; 83: 346-356
- Specific tricyclic antidepressant binding sites in rat brain.Nature. 1979; 281: 148-150
- Studies on human blood platelets in affective disorders.Psychopharmacology. 1979; 60: 131-135
- Localisation of tricyclic antidepressant binding sites on serotonin nerve terminals in rat hypothalamus.J Neurochem. 1981; 37: 40-42
- Complex inhibition of 3H-imipramine binding by serotonin and non tricyclic serotonin uptake blockers.J Neurochem. 1983; 40: 622-628
- Normalization of platelet 3H imipramine binding in depressed patients during remission.Eur J Pharmacol. 1982; 85: 357-358
- Altered platelet 3H-imipramine binding in schizoaffective and depressive disorders.Biol Psychiatry. 1983; 18: 923-927
- Imipramine treatment differentially affects platelet 3H-imipramine binding and serotonin uptake in depressed patients.Life Sci. 1985; 36: 795-799
- Seasonal variations in biochemical factors related to depressive illness.J Affect Disord. 1980; 2: 249-255
- Alteration of platelet 3H-imipramine binding in mildly depressed patients correlates with disease severity.Biol Psychiatry. 1985; 20: 340-343
- Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients.Nature. 1976; 262: 596-598
- Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogeneous depression.Psychopharmacology. 1979; 65: 141-147
- Seasonal variation in platelet 3H-imipramine binding: Comparable values in control and depressed populations.Psychiatry Res. 1984; 11: 127-131
- Uptake of 14C-5-hydroxytryptamine by human and rat platelets and its pharmacological inhibition. A comparative kinetic analysis.Arch Pharmacol. 1976; 296: 59-65
- Seasonality in biochemical determinations: A source of variance and a clue to the temporal incidence of affective illness.Psychiatry Res. 1979; 1: 53-60
- Lack of association between 3H-imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients.Neuropharmacology. 1983; 22: 1211-1214
- Platelet 3H-imipramine binding and red blood cell choline m affective disorders; indications of heterogeneous pathogenesis.Biol Psychiatry. 1983; 18: 715-719
Article info
Publication history
Received in revised form:
August 10,
1985
Received:
May 28,
1985
Identification
Copyright
© 1986 Published by Elsevier Inc.
