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Abstract
Two previous postmortem studies reported an increased thickness of the corpus callosum
in schizophrenic patients compared to psychiatric controls. We report an in vivo study
of the corpus callosum in schizophrenic patients (![Math Eq]()
) and healthy controls (![Math Eq]()
) using magnetic resonance (MR) brain imaging. A significant increase in mean callosal
thickness was found in the middle and anterior, but not the posterior, parts of the
callosal body. However, when the patients and controls were compared by gender and
handedness schizophrenic men were found not to differ from control men in callosal
thickness, regardless of handedness, whereas schizophrenic women were found to have
a highly significant increase in callosal middle and anterior thickness compared to
control women The data suggest that increased callosal thickness in schizophrenia
is gender related, a factor that is not considered by postmortem studies. The implications
of increased callosal dimensions in female schizophrenics are discussed.
) and healthy controls (
) using magnetic resonance (MR) brain imaging. A significant increase in mean callosal
thickness was found in the middle and anterior, but not the posterior, parts of the
callosal body. However, when the patients and controls were compared by gender and
handedness schizophrenic men were found not to differ from control men in callosal
thickness, regardless of handedness, whereas schizophrenic women were found to have
a highly significant increase in callosal middle and anterior thickness compared to
control women The data suggest that increased callosal thickness in schizophrenia
is gender related, a factor that is not considered by postmortem studies. The implications
of increased callosal dimensions in female schizophrenics are discussed.To read this article in full you will need to make a payment
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Article info
Publication history
Received in revised form:
September 30,
1985
Received:
June 26,
1985
Identification
Copyright
© 1986 Published by Elsevier Inc.
