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Research Article| Volume 21, ISSUE 3, P263-273, March 1986

Central error-correcting behavior in schizophrenia and depression

  • Robert C. Malenka
    Affiliations
    From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA and Palo Alto Veterans Administration Medical Center, Palo Alto, CA USA
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  • Ronald W. Angel
    Affiliations
    the Department of Neurology, Palo Alto Veterans Administration Medical Center and Stanford University School of Medicine USA
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  • Sue Thiemann
    Affiliations
    From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA and Palo Alto Veterans Administration Medical Center, Palo Alto, CA USA
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  • Charles J. Weitz
    Affiliations
    the Division of Neurosurgery, Stanford University School of Medicine USA
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  • Philip A. Berger
    Correspondence
    Address reprint requests to Dr. Philip A. Berger, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305 USA.
    Affiliations
    From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA and Palo Alto Veterans Administration Medical Center, Palo Alto, CA USA
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      Abstract

      A previous study suggested that schizophrenic subjects exhibit an impaired ability to correct their own errors of movement without using exteroceptive signals. However, the performance of schizophrenic subjects was compared to that of only one other psychiatric group (alcoholic subjects), and a relatively small number of subjects was studied. To investigate the specificity of the postulated impairment, 9 schizophrenic, 11 depressed, and 8 normal subjects performed a tracking task designed to prevent the use of exteroceptive cues in correcting errors of movement. The depressed and normal groups did not differ significantly on any performance measure, but the schizophrenic subjects again demonstrated a gross impairment in correcting errors, yet no impairment in initiating correct responses. These findings suggest that the impaired ability to monitor ongoing motor behavior on the basis of internal, self-generated cues may be specific to schizophrenia among major psychiatric disorders.
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