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Abstract
With a newly developed system of brain electrical activity mapping we studied 10 right-handed,
neuroleptic-treated schizophrenics (five of the disorganized, five of the paranoid
type, corresponding to 295.1 and .3 in DSM-III), compared with 10 normal controls.
Increasingly complex motor tasks were used for cortical activation, all functional
states being referenced to resting states recorded after a special relaxation program.
We found higher delta and theta amplitudes during rest, as noted in previous studies,
and lower beta power values. As a major result, however, we found a widespread left
hemisphere dysfunction in schizophrenics, predominantly in the left primary sensory
and motor areas. Additionally, we found signs of a “compensatory” overactivation in
patients in motor tasks, when this hemisphere is not “used” by normal persons. The
results support our findings obtained with this method during multisensory motor coordination
in schizophrenia. The results in these patients suggest that these are not merely
vigilance, attention, or motivation dysfunctions, but rather specific cortical correlates
of impaired motor performance.
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Article info
Publication history
Received in revised form:
March 30,
1985
Received:
January 2,
1985
Footnotes
☆This study was performed at the Service de Neurologie, Hôpital Sainte Anne, and the Unité de Recherches Neuropsychologiques (U.111 de l'INSERM), Paris, France.
☆☆Supported in part by the Deutsche Forschungsgemeinschaft (DFG Gu 207/1-1), Bonn, FRG.
★Dedicated to Prof. Hippius, Munich, on his 60th birthday.
Identification
Copyright
© 1986 Published by Elsevier Inc.
