Research Article| Volume 20, ISSUE 11, P1167-1173, November 1985

Association between amino acid alterations and hallucinations in alcoholic patients

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      Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma ratio of its precursor tryptophan over other amino acids competing with it for brain entry. Similarly, brain dopamine depends on the plasma ratio of its precursors phenylalanine and dopamine over their competitors. Amino acid abnormalities are common in alcoholics. For this reason, we assessed whether alcoholics who had experienced hallucinations have alterations in amino acids believed to be associated with neurotransmitter modifications. Patients with a history of hallucinations were found to have a tryptophan ratio significantly lower than that of patients without such a history, and a tyrosine + phenylalanine ratio significantly higher. These data suggest that amino acid abnormalities believed to result in decreased brain serotonin and in increased brain dopamine render certain individuals more vulnerable to hallucinatory experiences.
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        • Branchey L.
        • Branchey M.
        • Shaw S.
        • Lieber C.S.
        Relationship between changes in plasma amino acids and depression in alcoholic patients.
        Am J Psychiatry. 1984; 141: 1212-1215
        • Denkla W.D.
        • Dewey H.K.
        The determination of tryptophan in plasma, liver and urine.
        J Lab Clin Med. 1967; 69: 160-169
        • Goetz C.G.
        • Tanner C.M.
        • Klawans H.L.
        Pharmacology of hallucinations induced by long-term drug therapy.
        Am J Psychiatry. 1982; 139: 494-497
        • Ikeda M.
        • Levitt M.
        • Udenfriend S.
        Hydroxylation of phenlalanine by purified preparations of adrenal and brain tyrosine hydroxylase.
        Biochem Biophys Res Comm. 1965; 18: 482-488
        • Jacobs B.L.
        • Trulson M.E.
        Mechanisms of action of LSD.
        Am Sci. 1983; 67: 396-404
        • Morgan M.Y.
        • Milson J.P.
        • Sherlock S.
        Plasma ratio of valine, leucine and isoleucine to phenylalanine and tyrosine in liver disease.
        Gut. 1978; 19: 1068-1073
        • Nausieda P.A.
        • Tanner C.M.
        • Klawans H.L.
        Serotonergically active agents in levodopa induced psychiatric toxicity reactions.
        in: Fahn S. Calne D.R. Shoulson I. Advances in Neurology, 37: Experimental Therapeutics of Movement Disorders. Raven Press, New York1983
        • Pardridge W.M.
        • Oldendorf W.H.
        Transport of metabolic substrates through the blood-barrier.
        J Neurochem. 1977; 28: 5-12
        • Shaw S.
        • Lieber C.S.
        Plasma amino acid abnormalities in the alcoholic: Respective role of ethanol, nutrition and liver injury.
        Gastroenterology. 1978; 74: 677-682
        • Trulson M.E.
        • Preusler D.W.
        • Trulson V.M.
        Differential effect of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats.
        J Pharmacol Exp Ther. 1984; 228: 94-102
        • Wurtman R.J.
        • Hefti F.
        • Melamed E.
        Precursor control of neurotransmitter synthesis.
        Pharmacol Rev. 1981; 32: 315-335