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A family history of depression (but no alcoholism), a history of bipolarity, and a history of nonsuppressor status on the Dexamethasone Suppression Test (DST) have all been positively associated with each other in previous studies. We divided depressives into three mutually exclusive groups, using the three historical parameters described above. Group A included those who were nonsuppressors at index. Group B included normal suppressors at index who met one of the following three criteria: (1) past history of a nonsuppressing DST, (2) past history of a mania, and (3) family history of depression (but no alcoholism). The remaining suppressors at index made up Group C. We found that Groups A and B show a phase advance (an earlier nadir) in the predexamethasone circadian curve for cortisol. Adrenocorticotrophic hormone (ACTH) varies in part (but not solely) with cortisol and may separate the groups.
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- Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC1980 (DSM-III) 3rd ed.
- The dexamethasone suppression test for melancholia.Br J Psychiatry. 1982; 140: 292
- Dexamethasone suppression test response in major depression: Stability across hospitalizations.Psychiatry Res. 1982; 8: 179
- Plasma ACTH and cortisol levels in depressed patients: Relation to dexamethasone suppression test.Life Sci. 1981; 29: 931
- Plasma ACTH and cortisol concentrations before and after dexamethasone.Psychiatry Res. 1982; 7: 87
- Arch Gen Psychiatry. 1985; (in press)
- Dexamethasone suppression test in primary depression: Significance of family history and psychosis.Biol Psychiatry. 1982; 17: 41
- Hypothalamic-pituitary-adrenal axis activity in depressive illness.Arch Gen Psychiatry. 1980; 37: 737
- Subtypes of unipolar depression distinguished by the dexamethasone suppression test.J Affect Disord. 1982; 4: 21
☆Supported in part by USPHS-NIMH Grant 34697 and grant RR 59 from the General Clinical Research Centers Program, NIH.
© 1985 Published by Elsevier Inc.