This paper is only available as a PDF. To read, Please Download here.
Erythrocyte membrane Mg2+ ATPase and Na+ -K+ ATPase were measured in patients with affective disorder, their well relatives, and normal controls during euthymic moods. On the average, the Mg2+ ATPase activity was high in subjects belonging to affective disorder families. However, the difference between normal and affective disordered individuals was not statistically significant. Only the well individuals from affective disorder pedigrees as a group had significantly higher than normal Mg2+ ATPase activity (p > 0.05). The Na+ - K+ ATPase activity was similar for all the groups, including normal, bipolar manic-depressive (with or without lithium), unipolar depressive, and well individuals. Lithium treatment did not seem to have any effect on Mg2+ ATPase. Even though the values of Na+ -K+ ATPase in the lithium-treated group were high, it is not certain that this was due to lithium per se.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Activity of erythrocyte NaK-ATPase in manic patients.J Neurochem. 1980; 38: 258-260
- Johnson N. Johnson S. Lithium in Medical Practice. University Park Press, Baltimore1978: 173-182
- Lithium transport across the RBC membrane: A study of genetic factors.Arch Gen Psychiatry. 1980; 37: 80-81
- Amish study V: Li-Na counter transport and COMT in bipolar pedigrees.Am J Psychiatry. 1984; (in press)
- Johnson N. Johnson S. Lithium in Medical Practice. University Park Press, Baltimore1978: 183-192
- The effect of lithium treatment on erythrocyte membrane ATPase activities and erythrocyte ion content.Br J Clin Pharmacol. 1978; 5: 323-329
- Deficiency of erythrocyte pump activity in bipolar manic-depressive psychosis.Life Sci. 1975; 15: 1739-1748
- Increased erythrocyte Na+ pump and Na-K-ATPase activity during lithium therapy.Res Commun Chem Pathol Pharmacol. 1976; 14: 117-126
- RBC membrane adenosine triphosphatase activities in patients with major affective disorders.Arch Gen Psychiatry. 1983; 40: 1021-1026
- Protein measurement with the Folin phenol reagent.J Biol Chem. 1951; 193: 265-275
- Intracellular lithium concentration and clinical response: Towards a membrane theory of depression.J Psychiat Res. 1973; 10: 9-18
- Vanadium and affective disorders.Biol Psychiatry. 1983; 18: 103-112
- Vanadium, a possible aetiological factor in manic depressive illness.IRCS Med Ser. 1980; 8: 446-447
- Erythrocyte membrane cation carrier in depressive illness.Psychol Med. 1973; 3: 502-508
- Lithium therapy and erythrocyte membrane cation carrier.Psychopharmacologia. 1974; 37: 81-86
- Red cell ouabain-sensitive Na+-K+-adenosine triphosphatase: A state marker in affective disorder inversely related to plasma cortisol.Biol Psychiatry. 1982; 17: 981-992
- Erythrocyte membrane adenosine triphosphatase activities in patients with endogenous depression and healthy subjects.Eur J Clin Invest. 1981; 11: 61-64
- Schizophrenia and Affective Disorders Schedule, Life-Time Version.Biometrics Research, New York1977
- Effects of chronic dietary lithium on activity and regulation of (Na+, K+)-adenosine triphosphatase in rat brain.Biochem Pharmacol. 1980; 29: 2819-2823
- A micro colorimetric method for the determination of inorganic phosphorus.J Biol Chem. 1953; 202: 678-685
- Cell membrane anomaly in genetically determined manic-depressive illness.Neuropsychobiology. 1981; 7: 185-187
- Erythrocyte lithium transport variables as a marker for manic-depressive disorder.Neuropsychobiology. 1983; 9: 94-98
- Effect of electroconvulsive therapy on erythrocyte adenosine triphosphatase activity in depressive illness.Br J Psychiatry. 1980; 137: 343-345
Received in revised form: December 10, 1984
Received: August 11, 1984
© 1985 Published by Elsevier Inc.