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Abstract
Red blood cells from 18 lithium carbonate-treated patients with bipolar affective
disorder and 12 normal volunteers were analyzed using 1H-nuclear magnetic resonance (NMR) spectroscopy. The spectra were analyzed for alanine,
adenosine triphosphate (ATP), choline, 2,3-diphosphoglycerol, glucose, glutathione,
glycine, and lactate. Significant elevations of choline and lactate were found in
the lithium-treated patients compared with normal, unmedicated subjects. The elevation
of lactate due to anaerobic metabolism in the red blood cells was further investigated
via fluoremetric analysis and appears to be caused by blood standing at room temperature.
The observed increases in red blood cell choline are sufficiently high and statistically
significant to warrant additional studies on the dramatic effects of lithium on this
red cell metabolite, which might be important for an understanding of its mechanism
of action in psychiatric disorders.
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Article info
Publication history
Received in revised form:
May 16,
1985
Received:
August 3,
1984
Identification
Copyright
© 1985 Published by Elsevier Inc.
