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Research Article| Volume 20, ISSUE 12, P1267-1276, December 1985

Anterior cerebellar vermal stimulation: Effect on behavior and basal forebrain neurochemistry in rat

DOI:https://doi.org/10.1016/0006-3223(85)90111-8
Anterior cerebellar vermal stimulation: Effect on behavior and basal forebrain neurochemistry in rat
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      Abstract

      Stimulation of the anterior cerebellar vermis (ACV) has been shown to be of therapeutic value in several patients with chronic intractable psychiatric disorders, although the mechanism of action of ACV stimulation remains obscure. The present study sought to clarify how cerebellar stimulation might function by investigating the behavioral and biochemical effects of ACV stimulation in rats. Stimulation was found to increase the amplitude of the acoustic startle response and to produce a borderline enhancement of the potentiated startle effect, results that were interpreted as evidence that ACV stimulation enhances responsiveness to significant environmental cues. A concurrent increase in dopamine turnover and a decrease in serotonin release in the nucleus accumbens suggest possible mechanisms of action of the stimulation. It is proposed that cerebellar stimulation may exert a positive therapeutic effect only in Type II schizophrenia (negative symptomatology), a category of cases possibly associated with an underactive mesolimbic dopamine pathway and, hence, not responsive to neuroleptic treatment.
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      Article info

      Publication history

      Received in revised form: June 22, 1985
      Received: March 25, 1985

      Identification

      DOI: https://doi.org/10.1016/0006-3223(85)90111-8

      Copyright

      © 1985 Published by Elsevier Inc.

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