Research Article| Volume 20, ISSUE 12, P1267-1276, December 1985

Anterior cerebellar vermal stimulation: Effect on behavior and basal forebrain neurochemistry in rat

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      Stimulation of the anterior cerebellar vermis (ACV) has been shown to be of therapeutic value in several patients with chronic intractable psychiatric disorders, although the mechanism of action of ACV stimulation remains obscure. The present study sought to clarify how cerebellar stimulation might function by investigating the behavioral and biochemical effects of ACV stimulation in rats. Stimulation was found to increase the amplitude of the acoustic startle response and to produce a borderline enhancement of the potentiated startle effect, results that were interpreted as evidence that ACV stimulation enhances responsiveness to significant environmental cues. A concurrent increase in dopamine turnover and a decrease in serotonin release in the nucleus accumbens suggest possible mechanisms of action of the stimulation. It is proposed that cerebellar stimulation may exert a positive therapeutic effect only in Type II schizophrenia (negative symptomatology), a category of cases possibly associated with an underactive mesolimbic dopamine pathway and, hence, not responsive to neuroleptic treatment.
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        • Angrist B.
        • Peselow E.
        • Rubinstein M.
        • Corwin J.
        • Rotrosen J.
        Partial improvement in negative schizophrenic symptoms after amphetamine.
        Psychopharmacology. 1982; 78: 128-130
        • Bowers M.D.
        Central dopamine turnover in schizophrenic syndromes.
        Arch Gen Psychiatry. 1974; 31: 50-54
        • Bridger W.H.
        • Mandel I.J.
        The effects of dimethoxyphenylethylamine and mescaline on classical conditioning in rats as measured by the potentiated startle response.
        Life Sci. 1967; 6: 775-781
        • Chan-Palay V.
        Cerebellar Dentate Nucleus: Organization, Cytology and Transmitters.
        in: Springer-Verlag, Heidelberg1977: 199-207
        • Crow T.J.
        Two syndromes in schizophrenia?.
        TINS. 1982; 5: 351-354
        • Davis M.
        Neurochemical modulation of sensory-motor reactivity: Acoustical and tactile startle reflexes.
        Neurosci Biobehav Rev. 1980; 4: 241-263
        • Davis M.
        • Sollberger A.
        Twenty-four hour periodicity of the startle response in rats.
        Psychoneural Sci. 1971; 25: 1
        • Davis M.
        • Svensson T.H.
        • Aghajanian G.K.
        Effects of d- and l-amphetamine on habituation and sensitization of the acoustic startle response in rats.
        Psychopharmacologia. 1975; 43: 1-11
        • Dempesy C.W.
        • Tootle D.M.
        • Fontana C.J.
        • Fitzjarrell A.T.
        • Garey R.E.
        • Heath R.G.
        Stimulation of the paleocerebellar cortex of the cat: Increased rate of synthesis and release of catecholamines at limbic sites.
        Biol Psychiatry. 1983; 18: 127-132
        • Dill R.E.
        • Jones D.L.
        • Gillin J.C.
        • Murphy G.
        Behavioral effects of systemic l-DOPA and direct application of dopamine to mesolimbic forebrain in nonhuman primates.
        Soc Neurosci Abst. 1978; 4: 219
        • Gerlach J.
        • Luhdorf K.
        The effect of l-DOPA on young patients with simple schizophrenia treated with neuroleptic drugs.
        Psychopharmacologia. 1975; 44: 105-110
        • Heath R.G.
        Schizophrenia: Biochemical and physiological aberrations.
        Int J Neuropsychiatry. 1966; 2: 597-610
        • Heath R.G.
        Modulation of emotion with a brain pacemaker: Treatment for intractable psychiatric illness.
        J Nerv Ment Dis. 1977; 165: 300-317
        • Heath R.G.
        • Dempesy C.W.
        • Fontana C.J.
        • Myers W.A.
        Cerebellar stimulation: Effects on septal region, hippocampus, and amygdala of cats and rats.
        Biol Psychiatry. 1978; 13: 501-529
        • Heath R.G.
        • Dempesy C.W.
        • Fontana C.J.
        • Fitzjarrell A.T.
        Feedback loop between cerebellum and septal-hippocampal sites: Its role in emotion and epilepsy.
        Biol Psychiatry. 1980; 15: 541-556
        • Heath R.G.
        • Llewellyn R.C.
        • Rouchell A.M.
        The cerebellar pacemaker for intractable behavioral disorders and epilepsy: Follow-up report.
        Biol Psychiatry. 1980; 15: 243-256
        • Jackson V.
        • Glassgold J.
        • Miller C.
        • Snider S.
        Hypersensitivity of rats with chronic cerebellar lesions to abnormal behaviors induced by apomorphine.
        Soc Neurosci Abst. 1980; 6: 599
        • Jacobs B.L.
        • Trulson M.E.
        Dreams, hallucinations, and psychosis—The serotonin connection.
        TINS. 1979; 2: 276-280
        • Mesulam N.M.
        • Geschwind N.
        On the possible role of neocortex and limbic connections in the process of attention and schizophrenia: Clinical cases of inattention in man and experimental anatomy in monkey.
        J Psychiatr Res. 1978; 14: 249-259
        • Riklan M.
        • Cullinan T.
        • Cooper I.S.
        Tension reduction and alerting in man following chronic cerebellar stimulation for the relief of spasticity or intractable seizures.
        J Nerv Ment Dis. 1977; 164: 176-181
        • Snider R.S.
        • Maiti A.
        • Snider S.R.
        Cerebellar pathways to ventral midbrain and nigra.
        Exp Neurol. 1976; 53: 714-728
        • Snider S.R.
        Cerebellar pathology in schizophrenia—Cause or consequence?.
        Neurosci Biobehav Rev. 1982; 6: 47-53
        • Stevens J.R.
        • Wilson K.
        • Foote W.
        GABA blockade, dopamine and schizophrenia: Experimental studies in the cat.
        Psychopharmacologia. 1974; 39: 105-119
        • Tabaddor K.
        • Wolfson L.
        • Sharpless N.
        • Cooper I.
        Ventricular fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in patients with movement disorders.
        Neurology. 1978; 28: 1249-1253
        • Ungerstedt U.
        • Avemo A.
        • Ljungberg T.
        • Ranje C.
        Animal models of parkinsonism.
        Adv Neurol. 1973; 3: 257-271