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Research Article| Volume 20, ISSUE 10, P1109-1116, October 1985

The effect of nonsedating doses of diazepam on regional cerebral blood flow

DOI:https://doi.org/10.1016/0006-3223(85)90010-1
The effect of nonsedating doses of diazepam on regional cerebral blood flow
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      Abstract

      Drugs like diazepam induce tranquilization in small doses and sedation in larger quantities. Regional cerebral blood flow (rCBF) was measured before and 5 min after the intravenous administration of nonsedating doses of diazepam or placebo (given on a double-blind basis) to 20 right-handed volunteers. Subjects who received diazepam showed marked right hemispheric rCBF decreases, especially in the frontal lobe, whereas controls did not show significant differences between the two sets of values. None of the subjects became sleepy during the experiment.
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      Article info

      Publication history

      Received in revised form: March 26, 1985
      Received: November 13, 1984

      Footnotes

      ☆Supported by NIMH Grant MH 38627.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(85)90010-1

      Copyright

      © 1985 Published by Elsevier Inc.

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