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We treated 12 chronic schizophrenic inpatients with fenfluramine, an anorexigenic drug that depletes serotonin, to test the hypothesis that the “negative” symptoms of schizophrenia might be related to brain serotonin activity. We measured change in both positive and negative symptoms in a double-blind, parallel-design trial of fenfluramine or placebo. Negative symptoms improved over time in some individuals within the active treatment group, but not in individuals within the placebo group. However, group comparisons of active treatment versus placebo were not significant.
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Received in revised form: May 13, 1985
Received: February 14, 1985
☆Supported in part by NIMH Grant MH-30854 to the Norris Mental Health Clinical Research Center at Stanford University and a grant from the Research Service of the Veterans Administration to the Schizophrenia Biologic Research Center at Palo Alto Veterans Administration Medical Center.
© 1985 Published by Elsevier Inc.