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Abstract
Serotonin (5-HT) uptake into platelets from psychiatric patients and controls was
measured in the morning and afternoon. Uptake varied with time of day in both groups
studied, resulting in four recognizable patterns. Two patterns occurred in the majority
of controls. In contrast, uptake patterns in the psychiatric patients were more variable,
with each of the four patterns clearly represented. However, except for the fact that
uptake was significantly decreased throughout the day in depressed patients, the patterns
were not otherwise linked statistically to clinical condition. In any event, the greater
variability of daily 5-HT uptake patterns in patients suggests that psychiatric disorders
linked presumably to central nervous system (CNS) dysfunction are in some way reflected
by labile platelet 5-HT pharmacokinetics.
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Article info
Publication history
Received in revised form:
May 9,
1985
Received:
May 1,
1984
Identification
Copyright
© 1985 Published by Elsevier Inc.
