Research Article| Volume 20, ISSUE 10, P1039-1046, October 1985

Abnormal cerebrospinal fluid protein indices in schizophrenia

      This paper is only available as a PDF. To read, Please Download here.


      Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective IgG production within the central nervous system (CNS). In comparison with previously determined reference values, 7 of 24 (29%) subjects showed increased blood-brain barrier permeability, and 8 of 24 (33%) demonstrated elevated endogenous CNS IgG production. One of these eight also demonstrated oligoclonal banding on high-resolution protein electrophoresis of the CSF.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Axelsson R.
        • Martensson E.
        • Alling C.
        Impairment of the blood-brain barrier as an aetiological factor in paranoid psychosis.
        Br J Psychiatry. 1982; 141: 273-281
        • Bock E.
        Immunoglobulins, prealbumin, transferrin, albumin, and alpha2-macroglobulin in cerebrospinal fluid and serum in schizophrenic patients.
        Birth Defects. 1978; 14: 283-295
        • Bock E.
        • Rafaelsen O.J.
        Schizophrenia: Proteins in blood and cerebrospinal fluid.
        Dan Med Bull. 1974; 21: 93-105
        • Bruetsch W.L.
        • Bahr M.A.
        • Skobba J.S.
        • Dieter W.J.
        The group of dementia praecox patients with an increase of the protein content of the cerebrospinal fluid.
        J Nerv Ment Dis. 1942; 95: 669-679
        • Caroscio J.T.
        • Kochwa S.
        • Sacks H.
        • Cohen J.A.
        • Yahr M.D.
        Quantitative CSF IgG measurements in multiple sclerosis and other neurological diseases.
        Arch Neurol. 1983; 40: 409-413
        • Crow T.J.
        A re-evaluation of the viral hypothesis: Is psychosis the result of retroviral integration at a site close to the cerebral dominance gene?.
        Br J Psychiatry. 1984; 145: 243-253
        • DeLisi L.E.
        • Weinberger D.R.
        • Potkin S.
        • Neckers L.M.
        • Shiling D.J.
        • Wyatt R.J.
        Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients.
        Br J Psychiatry. 1981; 139: 513-518
        • Dencker S.J.
        • Malm U.
        Protein pattern of cerebrospinal fluid in mental disease.
        Acta Psychiatr Scand (Suppl). 1968; 203: 105-109
        • Ganrot K.
        • Laurell C.-B.
        Measurement of IgG and albumin content of cerebrospinal fluid, and its interpretation.
        Clin Chem. 1974; 20: 571-573
        • Hunter R.
        • Jones M.
        • Malleson A.
        Abnormal cerebrospinal fluid total protein and gamma-globulin levels in 256 patients admitted to a psychiatric unit.
        J Neurol Sci. 1969; 9: 11-38
        • Kaufmann C.A.
        • Weinberger D.R.
        • Yolken R.H.
        • Torrey E.F.
        • Potkin S.G.
        Viruses and schizophrenia.
        Lancet. 1983; ii: 1136-1137
        • Libikova H.
        Schizophrenia and viruses: Principles of etiologic studies.
        Adv Biol Psychiatry. 1983; 12: 20-51
        • Papadopoulos N.M.
        • Elin R.J.
        • Wilson D.M.
        Incidence of γ-globulin banding in a healthy population by high resolution electrophoresis.
        Clin Chem. 1982; 28: 707-708
        • Papadopoulos N.M.
        • Costello R.
        • Kay A.D.
        • Cutler N.R.
        • Rapoport S.I.
        Combined immunochemical and electrophoretic determinations of proteins in paired serum and cerebrospinal fluid samples.
        Clin Chem. 1984; 30: 1814-1816
        • Pearson E.K.
        Study of cerebrospinal fluid in schizophrenics—A review of the literature.
        Psychopharmacol Bull. 1973; 9: 59-62
        • Roos R.P.
        • Davis K.
        • Meltzer H.Y.
        Immunoglobulin studies in patients with psychiatric diseases.
        Arch Gen Psychiatry. 1985; 42: 124-128
        • Tibbling G.
        • Link H.
        • Ohman S.
        Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values.
        Scand J Clin Lab Invest. 1977; 37: 385-390
        • Torrey E.F.
        • Peterson M.R.
        The viral hypothesis of schizophrenia.
        Schizophr Bull. 1976; 2: 136-146
        • Torrey E.F.
        • Yolken R.H.
        • Winfrey C.J.
        Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay.
        Science. 1982; 216: 892-894
        • Tourtellotte W.W.
        • Potvin A.R.
        • Fleming J.O.
        • Murthy K.N.
        • Levy J.
        • Syndulko K.
        • Potvin J.H.
        Multiple sclerosis: Measurement and validation of central nervous system IgG synthesis rate.
        Neurology. 1980; 30: 240-244
        • Van Kammen D.P.
        • Sternberg D.E.
        Cerebrospinal fluid studies in schizophrenia.
        in: Wood J.H. Neurobiology of Cerebrospinal Fluid. Plenum, New York1980: 719-739
        • Weinberger D.R.
        • Torrey E.F.
        • Neophytides M.D.
        • Wyatt R.J.
        Lateral cerebral ventricular enlargement in chronic schizophrenia.
        Arch Gen Psychiatry. 1979; 36: 735-739