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Research Article| Volume 20, ISSUE 10, P1039-1046, October 1985

Abnormal cerebrospinal fluid protein indices in schizophrenia

DOI:https://doi.org/10.1016/0006-3223(85)90002-2
Abnormal cerebrospinal fluid protein indices in schizophrenia
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      Abstract

      Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective IgG production within the central nervous system (CNS). In comparison with previously determined reference values, 7 of 24 (29%) subjects showed increased blood-brain barrier permeability, and 8 of 24 (33%) demonstrated elevated endogenous CNS IgG production. One of these eight also demonstrated oligoclonal banding on high-resolution protein electrophoresis of the CSF.
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      Article info

      Publication history

      Received in revised form: April 22, 1985
      Received: February 26, 1985

      Identification

      DOI: https://doi.org/10.1016/0006-3223(85)90002-2

      Copyright

      © 1985 Published by Elsevier Inc.

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