Biological Psychiatry
Volume 71, Issue 5 , Pages 392-402 , 1 March 2012

Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism

  • Thomas V. Fernandez

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    • Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Stephan J. Sanders

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Ilana R. Yurkiewicz

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • A. Gulhan Ercan-Sencicek

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Young-Shin Kim

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Daniel O. Fishman

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Melanie J. Raubeson

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Youeun Song

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Katsuhito Yasuno

      Affiliations

    • Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Winson S.C. Ho

      Affiliations

    • Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Kaya Bilguvar

      Affiliations

    • Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Joseph Glessner

      Affiliations

    • The Center for Applied Genomics at The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Su Hee Chu

      Affiliations

    • Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • James F. Leckman

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Robert A. King

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Donald L. Gilbert

      Affiliations

    • Division of Neurology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Gary A. Heiman

      Affiliations

    • Department of Genetics, Rutgers University, Piscataway, New Jersey
    • ,
  • Jay A. Tischfield

      Affiliations

    • Department of Genetics, Rutgers University, Piscataway, New Jersey
    • ,
  • Pieter J. Hoekstra

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Bernie Devlin

      Affiliations

    • Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Hakon Hakonarson

      Affiliations

    • The Center for Applied Genomics at The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Shrikant M. Mane

      Affiliations

    • Keck Microarray Center, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Murat Günel

      Affiliations

    • Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
    • Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • ,
  • Matthew W. State

      Affiliations

    • Child Study Center, Yale University School of Medicine, New Haven, Connecticut
    • Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    • Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut
    • Center for Human Genetics and Genomics and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    • Corresponding Author InformationAddress correspondence to Matthew W. State, M.D., Ph.D., Yale University School of Medicine, Center for Human Genetics and Genomics and Department of Genetics, 230 South Frontage Road, New Haven, CT 06520

Received 17 May 2011 ,Revised 26 August 2011 ,Accepted 24 September 2011.

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PII: S0006-3223(11)01020-1

doi: 10.1016/j.biopsych.2011.09.034

Biological Psychiatry
Volume 71, Issue 5 , Pages 392-402 , 1 March 2012

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