Biological Psychiatry
Volume 68, Issue 2 , Pages 125-132 , 15 July 2010

Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study)

  • Marie-Laure Ancelin

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
    • Corresponding Author InformationAddress correspondence to Marie-Laure Ancelin, Ph.D., Inserm U888, Hopital La Colombiere, pav 42, 39, Avenue C, Flahault, BP 34493, 34093 Montpellier CEDEX 5, France
  • ,
  • Isabelle Carrière

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
  • ,
  • Jean-Philippe Boulenger

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
    • Service de Psychiatrie Adulte, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
  • ,
  • Alain Malafosse

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
    • University Hospital and School of Medicine of Geneva, University of Geneva, Switzerland
  • ,
  • Robert Stewart

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
    • Institute of Psychiatry, King's College London, London, United Kingdom
  • ,
  • Jean-Paul Cristol

      Affiliations

    • Laboratoire de Biochimie, Hopital Lapeyronie, CHU, Montpellier, France
  • ,
  • Karen Ritchie

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
  • ,
  • Isabelle Chaudieu

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
  • ,
  • Anne-Marie Dupuy

      Affiliations

    • Institut de la Santé et de la Recherche Médicale (Inserm) and University of Montpellier 1, Hopital La Colombiere, Centre Hospitalier Universitaire (CHU), Montpellier, France
    • Laboratoire de Biochimie, Hopital Lapeyronie, CHU, Montpellier, France

Received 18 December 2009 ,Revised 2 April 2010 ,Accepted 8 April 2010.

References 

  1. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. “Vascular depression” hypothesis. Arch Gen Psychiatry. 1997;54:915–922
  2. Rabe-Jablonska J, Poprawska I. Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission. Med Sci Monit. 2000;6:539–547
  3. Rozzini R, Bertozzi B, Barbisoni P, Trabucchi M. Low serum cholesterol and serotonin metabolism (Risk of depression is higher in elderly patients with lowest serum cholesterol values). BMJ. 1996;312:1298–1299
  4. Pizzi C, Manzoli L, Mancini S, Costa GM. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J. 2008;29:1110–1117
  5. Kim JM, Stewart R, Shin IS, Yoon JS. Vascular disease/risk and late-life depression in a Korean community population. Br J Psychiatry. 2004;185:102–107
  6. Blazer DG, Burchett BB, Fillenbaum GG. APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample. Am J Geriatr Psychiatry. 2002;10:515–520
  7. Brown SL, Salive ME, Harris TB, Simonsick EM, Guralnik JM, Kohout FJ. Low cholesterol concentrations and severe depressive symptoms in elderly people. BMJ. 1994;308:1328–1332
  8. Vogelzangs N, Suthers K, Ferrucci L, Simonsick EM, Ble A, Schrager M, et al. Hypercortisolemic depression is associated with the metabolic syndrome in late-life. Psychoneuroendocrinology. 2007;32:151–159
  9. Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science. 2005;308:1583–1587
  10. Polk DM, Naqvi TZ. Cardiovascular disease in women: Sex differences in presentation, risk factors, and evaluation. Curr Cardiol Rep. 2005;7:166–172
  11. LaRosa JC. Lipids and cardiovascular disease: Do the findings and therapy apply equally to men and women?. Womens Health Issues. 1992;2:102–111discussion:111–113
  12. Strandberg TE, Valvanne J, Tilvis RS. Serum lipids and depression. Lancet. 1993;341:433–434
  13. Shibata H, Kumagai S, Watanabe S, Suzuki T. Relationship of serum cholesterols and vitamin E to depressive status in the elderly. J Epidemiol. 1999;9:261–267
  14. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry. 2008;13:772–785
  15. Mahley RW, Rall SC. Apolipoprotein E: Far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 2000;1:507–537
  16. Fischer P, Gruenblatt E, Pietschmann P, Tragl KH. Serotonin transporter polymorphism and LDL-cholesterol. Mol Psychiatry. 2006;11:707–709
  17. Kim JM, Stewart R, Kim SW, Shin IS, Yang SJ, Yoon JS. Cholesterol and serotonin transporter polymorphism interactions in late-life depression. Neurobiol Aging. 2009;[published online ahead of print March 27]
  18. Ritchie K, Artero S, Beluche I, Ancelin ML, Mann A, Dupuy AM, et al. Prevalence of DSM-IV psychiatric disorder in the French elderly population. Br J Psychiatry. 2004;184:147–152
  19. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59:22–33
  20. Radloff L. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401
  21. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198
  22. Dupuy AM, Carriere I, Scali J, Cristol JP, Ritchie K, Dartigues JF, et al. Lipid levels and cardiovascular risk in elderly women: A general population study of the effects of hormonal treatment and lipid-lowering agents. Climacteric. 2008;11:74–83
  23. Ritchie K, Jaussent I, Stewart R, Dupuy AM, Courtet P, Ancelin ML, et al. Association of adverse childhood environment and 5-HTTLPR genotype with late-life depression. J Clin Psychiatry. 2009;70:1281–1288
  24. Commenges D, Letenneur L, Joly P, Alioum A, Dartigues JF. Modelling age-specific risk: Application to dementia. Stat Med. 1998;17:1973–1988
  25. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS. Vascular risk factors and incident late-life depression in a Korean population. Br J Psychiatry. 2006;189:26–30
  26. Wardle J, Armitage J, Collins R, Wallendszus K, Keech A, Lawson A. Randomised Placebo Controlled Trial of Effect on Mood of Lowering Cholesterol Concentration (Oxford: Cholesterol Study Group). BMJ. 1996;313:75–78
  27. Stewart RA, Sharples KJ, North FM, Menkes DB, Baker J, Simes J. Long-term assessment of psychological well-being in a randomized placebo-controlled trial of cholesterol reduction with pravastatin (The LIPID Study Investigators). Arch Intern Med. 2000;160:3144–3152
  28. Aijanseppa S, Kivinen P, Helkala EL, Kivela SL, Tuomilehto J, Nissinen A. Serum cholesterol and depressive symptoms in elderly Finnish men. Int J Geriatr Psychiatry. 2002;17:629–634
  29. Partonen T, Haukka J, Virtamo J, Taylor PR, Lonnqvist J. Association of low serum total cholesterol with major depression and suicide. Br J Psychiatry. 1999;175:259–262
  30. Steegmans PH, Hoes AW, Bak AA, van der Does E, Grobbee DE. Higher prevalence of depressive symptoms in middle-aged men with low serum cholesterol levels. Psychosom Med. 2000;62:205–211
  31. Morgan RE, Palinkas LA, Barrett-Connor EL, Wingard DL. Plasma cholesterol and depressive symptoms in older men. Lancet. 1993;341:75–79
  32. Almeida OP, Flicker L, Norman P, Hankey GJ, Vasikaran S, van Bockxmeer FM, et al. Association of cardiovascular risk factors and disease with depression in later life. Am J Geriatr Psychiatry. 2007;15:506–513
  33. Bots S, Tijhuis M, Giampaoli S, Kromhout D, Nissinen A. Lifestyle- and diet-related factors in late-life depression—A 5-year follow-up of elderly European men: The FINE study. Int J Geriatr Psychiatry. 2008;23:478–484
  34. Engelberg H. Low serum cholesterol and suicide. Lancet. 1992;339:727–729
  35. Barter P, Gotto AM, laRosa JC, Maroni J, Szarek M, Grundy SM, et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007;357:1301–1310
  36. Horsten M, Wamala SP, Vingerhoets A, Orth-Gomer K. Depressive symptoms, social support, and lipid profile in healthy middle-aged women. Psychosom Med. 1997;59:521–528
  37. Sampietro T, Bigazzi F, Dal Pino B, Puntoni M, Bionda A. HDL: The “new” target of cardiovascular medicine. Int J Cardiol. 2006;108:143–154
  38. Panagiotakos DB, Pitsavos C, Chrysohoou C, Tsetsekou E, Papageorgiou C, Christodoulou G, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the Attica study. Eur Heart J. 2004;25:492–499
  39. Troisi A. Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?. Neurosci Biobehav Rev. 2009;33:125–132
  40. Marcus SM, Young EA, Kerber KB, Kornstein S, Farabaugh AH, Mitchell J, et al. Gender differences in depression: Findings from the star* D study. J Affect Disord. 2005;87:141–150
  41. Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry. 2006;163:109–114
  42. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006;38:218–222
  43. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009;41:47–55
  44. Ancelin ML, Ritchie K. Lifelong endocrine fluctuations and related cognitive disorders. Curr Pharm Des. 2005;11:4229–4252
  45. Sowers MR, Symons JP, Jannausch ML, Chu J, Kardia SR. Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the study of women's health across the nation (SWAN). Am J Med. 2006;119:S61–S68
  46. Westberg L, Eriksson E. Sex steroid-related candidate genes in psychiatric disorders. J Psychiatry Neurosci. 2008;33:319–330
  47. Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, et al. European guidelines on cardiovascular disease prevention in clinical practice: Executive summary. Eur Heart J. 2007;28:2375–2414

PII: S0006-3223(10)00393-8

doi: 10.1016/j.biopsych.2010.04.011

Biological Psychiatry
Volume 68, Issue 2 , Pages 125-132 , 15 July 2010