Biological Psychiatry
Volume 67, Issue 11 , Pages 1033-1039 , 1 June 2010

Seasonal Changes in Brain Serotonin Transporter Binding in Short Serotonin Transporter Linked Polymorphic Region-Allele Carriers but Not in Long-Allele Homozygotes

  • Jan Kalbitzer

      Affiliations

    • Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • Corresponding Author InformationAddress correspondence to Jan Kalbitzer, M.D., Ph.D., Charité Berlin - Campus Mitte, Department of Psychiatry at St. Hedwig Hospital, Große Hamburger Straße 5-11, 10115 Berlin, Germany
    • ,
  • David Erritzoe

      Affiliations

    • Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Klaus K. Holst

      Affiliations

    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Finn Å. Nielsen

      Affiliations

    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • Department of Informatics and Mathematical Modelling, Technical University of Denmark, Lyngby, Denmark
    • ,
  • Lisbeth Marner

      Affiliations

    • Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Szabolcs Lehel

      Affiliations

    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • PET and Cyclotron Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • ,
  • Tine Arentzen

      Affiliations

    • Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Terry L. Jernigan

      Affiliations

    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark
    • Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Hvidovre Hospital, Copenhagen, Denmark
    • ,
  • Gitte M. Knudsen

      Affiliations

    • Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    • Center for Integrated Molecular Brain Imaging, University of Copenhagen, Copenhagen, Denmark

Received 19 February 2009 ,Revised 19 November 2009 ,Accepted 19 November 2009.

References 

  1. Kasper S, Wehr TA, Bartko JJ, Gaist PA, Rosenthal NE. Epidemiological findings of seasonal changes in mood and behavior (A telephone survey of Montgomery County, Maryland). Arch Gen Psychiatry. 1989;46:823–833
  2. Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, et al. Seasonal affective disorder (A description of the syndrome and preliminary findings with light therapy). Arch Gen Psychiatry. 1984;41:72–80
  3. Carlsson A, Svennerholm L, Winblad B. Seasonal and circadian monoamine variations in human brains examined post mortem. Acta Psychiatr Scand Suppl. 1980;280:75–85
  4. Lambert G, Reid C, Kaye D, Jennings G, Esler M. Effect of sunlight and season on serotonin turnover in the brain. Lancet. 2002;360:1840–1842
  5. Lesch K, Bengel D, Heils A, Sabol S, Greenberg B, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–1531
  6. Canli T, Lesch K. Long story short: The serotonin transporter in emotion regulation and social cognition. Nat Neurosci. 2007;10:1103–1109
  7. Neumeister A, Pirker W, Willeit M, Praschak-Rieder N, Asenbaum S, Brücke T, et al. Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry. 2000;47:158–160
  8. Buchert R, Schulze O, Wilke F, Berding G, Thomasius R, Petersen K, et al. Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?. J Nucl Med. 2006;47:38–42
  9. Praschak-Rieder N, Willeit M, Wilson A, Houle S, Meyer J. Seasonal variation in human brain serotonin transporter binding. Arch Gen Psychiatry. 2008;65:1072–1078
  10. Ruhe HG, Booij J, Reitsma JB, Schene AH. Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: Effect of season and gender. Eur J Nucl Med Mol Imaging. 2009;36:841–849
  11. Rosenthal NE, Mazzanti CM, Barnett RL, Hardin TA, Turner EH, Lam GK, et al. Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Mol Psychiatry. 1998;3:175–177
  12. Gotlib IH, Joormann J, Minor KL, Hallmayer J. HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol Psychiatry. 2008;63:847–851
  13. Caspi A, Sugden K, Moffitt T, Taylor A, Craig I, Harrington H, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  14. Willeit M, Praschak-Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, et al. A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry. 2003;8:942–946
  15. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002;297:400–403
  16. Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biol Psychiatry. 2008;63:852–857
  17. van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, et al. Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. Am J Psychiatry. 2004;161:525–531
  18. Parsey RV, Hastings RS, Oquendo MA, Huang YY, Simpson N, Arcement J, et al. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry. 2006;163:52–58
  19. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry. 2000;47:643–649
  20. Praschak-Rieder N, Kennedy J, Wilson A, Hussey D, Boovariwala A, Willeit M, et al. Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: A [(11)C] DASB positron emission tomography study. Biol Psychiatry. 2007;62:327–331
  21. Reimold M, Smolka MN, Schumann G, Zimmer A, Wrase J, Mann K, et al. Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype. J Neural Transm. 2007;114:635–639
  22. Kalbitzer J, Frokjaer VG, Erritzoe D, Svarer C, Cumming P, Nielsen FA, et al. The personality trait openness is related to cerebral 5-HTT levels. Neuroimage. 2009;45:280–285
  23. Frokjaer VG, Vinberg M, Erritzoe D, Svarer C, Baare W, Budtz-Joergensen E, et al. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. Neuroimage. 2009;46:360–366
  24. Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbol S, Frokjaer VG, et al. MR-based automatic delineation of volumes of interest in human brain PET images using probability maps. Neuroimage. 2005;24:969–979
  25. Houle S, Ginovart N, Hussey D, Meyer JH, Wilson AA. Imaging the serotonin transporter with positron emission tomography: Initial human studies with [11C]DAPP and [11C]DASB. Eur J Nucl Med. 2000;27:1719–1722
  26. Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, et al. Linearized reference tissue parametric imaging methods: Application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab. 2003;23:1096–1112
  27. Knudsen GM, Pettigrew KD, Patlak CS, Hertz MM, Paulson OB. Asymmetrical transport of amino acids across the blood–brain barrier in humans. J Cereb Blood Flow Metab. 1990;10:698–706
  28. Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: A primer with examples. Hum Brain Mapp. 2002;15:1–25
  29. Reimold M, Slifstein M, Heinz A, Mueller-Schauenburg W, Bares R. Effect of spatial smoothing on t-maps: Arguments for going back from t-maps to masked contrast images. J Cereb Blood Flow Metab. 2006;26:751–759
  30. Canli T, Congdon E, Todd Constable R, Lesch KP. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biol Psychol. 2008;79:118–125
  31. Zald DH, Pardo JV. The neural correlates of aversive auditory stimulation. Neuroimage. 2002;16:746–753
  32. Hornung JP. The human raphe nuclei and the serotonergic system. J Chem Neuroanat. 2003;26:331–343
  33. Willeit M, Sitte H, Thierry N, Michalek K, Praschak-Rieder N, Zill P, et al. Enhanced serotonin transporter function during depression in seasonal affective disorder. Neuropsychopharmacology. 2008;33:1503–1513
  34. Rattray M, Baldessari S, Gobbi M, Mennini T, Samanin R, Bendotti C. p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. J Neurochem. 1996;67:463–472
  35. Jennings KA, Loder MK, Sheward WJ, Pei Q, Deacon RM, Benson MA, et al. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. J Neurosci. 2006;26:8955–8964
  36. Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S, et al. No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry. 2001;50:8–12
  37. Johansson C, Willeit M, Levitan R, Partonen T, Smedh C, Del Favero J, et al. The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality. Psychol Med. 2003;33:785–792

PII: S0006-3223(09)01425-5

doi: 10.1016/j.biopsych.2009.11.027

Biological Psychiatry
Volume 67, Issue 11 , Pages 1033-1039 , 1 June 2010

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