Biological Psychiatry
Volume 64, Issue 2 , Pages 89-97 , 15 July 2008

Shared Gene Expression Alterations in Schizophrenia and Bipolar Disorder

  • Ling Shao
    • ,
  • Marquis P. Vawter

      Affiliations

    • Corresponding Author InformationReprint requests to Marquis P. Vawter, Ph.D., Gillespie Neuroscience Research Facility, Functional Genomics Laboratory, Room 2119, University of California, Irvine, Irvine CA 92697-4260

Received 26 June 2007 ,Revised 6 November 2007 ,Accepted 8 November 2007.

References 

  1. Craddock N, O'Donovan MC, Owen MJ. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet. 2005;42:193–204
  2. Craddock N, Owen MJ. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry. 2005;186:364–366
  3. Craddock N, O'Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? (Implications for psychiatric nosology). Schizophr Bull. 2006;32:9–16
  4. Craddock N, O'Donovan MC, Owen MJ. Symptom dimensions and the Kraepelinian dichotomy. Br J Psychiatry. 2007;190:361;author reply 361–362
  5. Owen MJ, Craddock N, Jablensky A (2007): The Genetic Deconstruction of Psychosis. 33:905-911.
  6. Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry. 2004;9:406–416
  7. Iwamoto K, Bundo M, Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet. 2005;14:241–253
  8. Tomita H, Vawter MP, Walsh DM, Evans SJ, Choudary PV, Li J, et al. Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain. Biol Psychiatry. 2004;55:346–352
  9. Vawter MP, Tomita H, Meng F, Bolstad B, Li J, Evans S, et al. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: Implications for brain disorders. Mol Psychiatry. 2006;11:663–679
  10. Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J Royal Stat Soc B Methodol. 1995;57:289–300
  11. Vawter MP, Evans S, Choudary P, Tomita H, Meador-Woodruff J, Molnar M, et al. Gender-specific gene expression in post-mortem human brain: Localization to sex chromosomes. Neuropsychopharmacology. 2004;29:373–384
  12. Lee HK, Braynen W, Keshav K, Pavlidis P. ErmineJ: Tool for functional analysis of gene expression data sets. BMC Bioinformatics. 2005;6:269
  13. Erraji-Benchekroun L, Underwood MD, Arango V, Galfalvy H, Pavlidis P, Smyrniotopoulos P, et al. Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry. 2005;57:549–558
  14. Galfalvy HC, Erraji-Benchekroun L, Smyrniotopoulos P, Pavlidis P, Ellis SP, Mann JJ, et al. Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction. BMC Bioinformatics. 2003;4:37
  15. Altar CA, Jurata LW, Charles V, Lemire A, Liu P, Bukhman Y, et al. Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol Psychiatry. 2005;58:85–96
  16. Li JZ, Vawter MP, Walsh DM, Tomita H, Evans SJ, Choudary PV, et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum Mol Genet. 2004;13:609–616
  17. Li JZ, Meng F, Tsavaler L, Evans SJ, Choudary PV, Tomita H, et al. (2007): Sample matching by inferred agonal stress in gene expression analyses of the brain. 8:336.
  18. Atz M, Walsh D, Cartagena P, Li J, Evans S, Choudary P, et al. Methodological considerations for gene expression profiling of human brain. J Neurosci Meth. 2007;163:295–309
  19. Mexal S, Berger R, Adams CE, Ross RG, Freedman R, Leonard S. Brain pH has a significant impact on human postmortem hippocampal gene expression profiles. Brain Res. 2006;1106:1–11
  20. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A. 2004;101:6062–6067
  21. Dranovsky A, Hen R. Hippocampal neurogenesis: Regulation by stress and antidepressants. Biol Psychiatry. 2006;59:1136–1143
  22. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003;301:805–809
  23. Harwood AJ. Neurodevelopment and mood stabilizers. Current molecular medicine. 2003;3:472–482
  24. Jarskog LF. Apoptosis in schizophrenia: Pathophysiologic and therapeutic considerations. Curr Opin Psychiatry. 2006;19:307–312
  25. Chen G, Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH, et al. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem. 1999;72:879–882
  26. McQuillin A, Rizig M, Gurling HM. A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenet Genomics. 2007;17:605–617
  27. Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A. 2005;102:15653–15658
  28. McCullumsmith RE, Meador-Woodruff JH. Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder. Neuropsychopharmacology. 2005;26:368–375
  29. Smith RE, Haroutunian V, Davis KL, Meador-Woodruff JH. Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia. Am J Psychiatry. 2001;158:1393–1399
  30. Balcar VJ, Nanitsos EK. Autoradiography of (3H)aspartate and glutamate transport in schizophrenia. Neuropsychopharmacology. 2006;31:685–686author reply 687–688
  31. Lauriat TL, Dracheva S, Chin B, Schmeidler J, McInnes LA, Haroutunian V. Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain. Neuroscience. 2006;137:843–851
  32. Berger UV, Hediger MA (2006): Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs. 211:595–606.
  33. Deng X, Shibata H, Ninomiya H, Tashiro N, Iwata N, Ozaki N, et al. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. BMC Psychiatry. 2004;4:21
  34. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59:1116–1127
  35. Newton SS, Duman RS. Regulation of neurogenesis and angiogenesis in depression. Curr Neurovasc Res. 2004;1:261–267
  36. Lee Y, Duman RS, Marek GJ. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006;398:328–332
  37. Duman RS. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromol Med. 2004;5:11–25
  38. Dias BG, Banerjee SB, Duman RS, Vaidya VA. Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology. 2003;45:553–563
  39. D'Sa C, Duman RS. Antidepressants and neuroplasticity. Bipolar Disord. 2002;4:183–194
  40. Jurata LW, Bukhman YV, Charles V, Capriglione F, Bullard J, Lemire AL, et al. Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures. J Neurosci Meth. 2004;138:173–188
  41. Thompson M, Lauderdale S, Webster MJ, Chong VZ, McClintock B, Saunders R, et al. Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain. Brain Res. 2007;1139:95–109
  42. Britsch S. The neuregulin-I/ErbB signaling system in development and disease (Advances in anatomy, embryology, and cell biology). Cell Biol. 2007;190:1–65
  43. Law A. Schizophrenia, IV: Neuregulin-1 in the human brain. Am J Psychiatry. 2003;160:1392
  44. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002;71:877–892
  45. Harrison PJ, Owen MJ. Genes for schizophrenia? (Recent findings and their pathophysiological implications). Lancet. 2003;361:417–419
  46. Sun X, Wang JF, Tseng M, Young LT. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci. 2006;31:189–196
  47. Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, et al. Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry. 2004;9:964–997
  48. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry. 2004;61:300–308
  49. Weis S, Llenos IC, Dulay JR, Elashoff M, Martinez-Murillo F, Miller CL. Quality control for microarray analysis of human brain samples: The impact of postmortem factors, RNA characteristics, and histopathology. J Neurosci Meth. 2007;165:198–209
  50. Arion D, Unger T, Lewis DA, Levitt P, Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry. 2007;62:711–721

PII: S0006-3223(07)01104-3

doi: 10.1016/j.biopsych.2007.11.010

Biological Psychiatry
Volume 64, Issue 2 , Pages 89-97 , 15 July 2008

Article Tools

* Image Usage & Resolution