Biological Psychiatry
Volume 60, Issue 8 , Pages 799-802 , 15 October 2006

Aggressive Behavior Linked to Corticotropin-Reactive Autoantibodies

  • Sergueï O. Fetissov

      Affiliations

    • Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationAddress reprint requests to Dr. Sergueï O. Fetissov, Groupe ADEN, Faculté de Médecine-Pharmacie, 22, Bld Gambetta, Rouen, 76183, Cedex 1, France
    • ,
  • Jarmila Hallman

      Affiliations

    • Department of Neuroscience, Uppsala University, Uppsala, Sweden
    • ,
  • Ida Nilsson

      Affiliations

    • Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Ann-Kari Lefvert

      Affiliations

    • Immunological Research Laboratory, Center for Molecular Medicine and Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
    • ,
  • Lars Oreland

      Affiliations

    • Department of Neuroscience, Uppsala University, Uppsala, Sweden
    • ,
  • Tomas Hökfelt

      Affiliations

    • Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

Received 4 November 2005 ,Revised 13 March 2006 ,Accepted 16 March 2006.

References 

  1. Anderberg UM, Uvnäs-Moberg K. Plasma oxytocin levels in female fibromyalgia syndrome patients. Z Rheumatol. 2000;59:373–379
  2. Bale TL, Davis AM, Auger AP, Dorsa DM, McCarthy MM. CNS region-specific oxytocin receptor expression: Importance in regulation of anxiety and sex behavior. J Neurosci. 2001;21:2546–2552
  3. Bosch OJ, Meddle SL, Beiderbeck DI, Douglas AJ, Neumann ID. Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci. 2005;25:6807–6815
  4. Burgdorf J, Panksepp J. The neurobiology of positive emotions. Neurosci Biobehav Rev. 2006;30:173–187
  5. Choleris E, Gustafsson JA, Korach KS, Muglia LJ, Pfaff DW, Ogawa S. An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A. 2003;100:6192–6197
  6. Chrousos GP, Gold PW. The concepts of stress and stress system disorders (Overview of physical and behavioral homeostasis). JAMA. 1992;267:1244–1252
  7. Coutinho A, Kazatchkine MD, Avrameas S. Natural autoantibodies. Curr Opin Immunol. 1995;7:812–818
  8. Dallman MF. Fast glucocorticoid actions on brain: Back to the future. Frontiers in Neuroendocrinology. 2005;26:103–108
  9. de Wied D, Diamant M, Fodor M. Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocrinol. 1993;14:251–302
  10. Demitrack MA, Kalogeras KT, Altemus M, Pigott TA, Listwak SJ, Gold PW. Plasma and cerebrospinal fluid measures of arginine vasopressin secretion in patients with bulimia nervosa and in healthy subjects. J Clin Endocrinol Metab. 1992;74:1277–1283
  11. Ebner K, Wotjak CT, Landgraf R, Engelmann M. Neuroendocrine and behavioral response to social confrontation: Residents versus intruders, active versus passive coping styles. Horm Behav. 2005;47:14–21
  12. Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene. Nat Genet. 2000;25:284–288
  13. Fetissov SO. Autoimmune component in anorexia and bulimia nervosa. In:  Fatemi SH editors. Neuropsychiatric Disorders and Infection. London: Taylor and Francis; 2004;p. 296
  14. Fetissov SO, Hallman J, Oreland L, af Klinteberg B, Grenbäck E, Hulting AL, et al. Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients. Proc Natl Acad Sci U S A. 2002;99:17155–17160
  15. Fetissov SO, Harro J, Jaanisk M, Järv A, Podar I, Allik J, et al. Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proc Natl Acad Sci U S A. 2005;102:14865–14870
  16. Griebel G, Simiand J, Serradeil-Le Gal C, Wagnon J, Pascal M, Scatton B, et al. Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. Proc Natl Acad Sci U S A. 2002;99:6370–6375
  17. Guilbert B, Dighiero G, Avrameas S. Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization. J Immunol. 1982;128:2779–2787
  18. Halasz J, Liposits Z, Kruk MR, Haller J. Neural background of glucocorticoid dysfunction-induced abnormal aggression in rats: Involvement of fear- and stress-related structures. Eur J Neurosci. 2002;15:561–569
  19. Haller J, Mikics E, Halasz J, Toth M. Mechanisms differentiating normal from abnormal aggression: Glucocorticoids and serotonin. Eur J Pharmacol. 2005;526:89–100
  20. Haller J, Toth M, Halasz J. The activation of raphe serotonergic neurons in normal and hypoarousal-driven aggression: A double labeling study in rats. Behav Brain Res. 2005;161:88–94
  21. Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, Stewart CL, et al. Positive selection of natural autoreactive B cells. Science. 1999;285:113–116
  22. Hill J. Biological, psychological and social processes in the conduct disorders. J Child Psychol Psychiatry. 2002;43:133–164
  23. Huber D, Veinante P, Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science. 2005;308:245–248
  24. Kastin AJ, Pan W. Peptide transport across the blood–brain barrier. Prog Drug Res. 2003;61:79–100
  25. Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B, et al. Cognition and immunity: Antibody impairs memory. Immunity. 2004;21:179–188
  26. Kratzer L, Hodgins S. Adult outcomes of child conduct problems: A cohort study. J Abnorm Child Psychol. 1997;25:65–81
  27. Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication. Frontiers Neuroendocrinol. 2004;25:150–176
  28. Lefkowitz RJ, Roth J, Pricer W, Pastan I. ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. Proc Natl Acad Sci U S A. 1970;65:745–752
  29. Legros JJ. Inhibitory effect of oxytocin on corticotrope function in humans: Are vasopressin and oxytocin ying-yang neurohormones?. Psychoneuroendocrinology. 2001;26:649–655
  30. Lim MM, Wang Z, Olazabal DE, Ren X, Terwilliger EF, Young LJ. Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature. 2004;429:754–757
  31. Lindberg E, Adlerberth I, Wold AE. Antibiotic resistance in Staphylococcus aureus colonising the intestines of Swedish infants. Clin Microbiol Infect. 2004;10:890–894
  32. Nelson RJ, Chiavegatto S. Molecular basis of aggression. Trends Neurosci. 2001;24:713–719
  33. Neumann ID. Involvement of the brain oxytocin system in stress coping: Interactions with the hypothalamo–pituitary–adrenal axis. Prog Brain Res. 2002;139:147–162
  34. Oldstone MB. Molecular mimicry and immune-mediated diseases. Faseb J. 1998;12:1255–1265
  35. O’Mahony R, Vaira D, Holton J, Basset C. Helicobacter pylori: Current status and future prospects. Sci Prog. 2004;87:269–296
  36. Pan W, Solomon B, Maness LM, Kastin AJ. Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide. Exp Biol Med (Maywood). 2002;227:609–615
  37. Scantamburlo G, Hansenne M, Fuchs S, Pitchot W, Pinto E, Reggers J, et al. AVP- and OT-neurophysins response to apomorphine and clonidine in major depression. Psychoneuroendocrinology. 2005;30:839–845
  38. Sewards TV, Sewards MA. Fear and power-dominance motivation: Proposed contributions of peptide hormones present in cerebrospinal fluid and plasma. Neurosci Biobehav Rev. 2003;27:247–267
  39. Stoehr JD, Cramer CP, North WG. Oxytocin and vasopressin hexapeptide fragments have opposing influences on conditioned freezing behavior. Psychoneuroendocrinology. 1992;17:267–271
  40. Swaab DF. Neuropeptides in hypothalamic neuronal disorders. Int Rev Cytol. 2004;240:305–375
  41. Swanson LW. Anatomy of the soul as reflected in the cerebral hemispheres: Neural circuits underlying voluntary control of basic motivated behaviors. J Comp Neurol. 2005;493:122–131
  42. Telegdy G, Vermes I. Effect of adrenocortical hormones on activity of the serotoninergic system in limbic structures in rats. Neuroendocrinology. 1975;18:16–26
  43. van Goozen SH, Matthys W, Cohen-Kettenis PT, Gispen-de Wied C, Wiegant VM, van Engeland H. Salivary cortisol and cardiovascular activity during stress in oppositional–defiant disorder boys and normal controls. Biol Psychiatry. 1998;43:531–539
  44. van Londen L, Kerkhof GA, van den Berg F, Goekoop JG, Zwinderman KH, Frankhuijzen-Sierevogel AC, et al. Plasma arginine vasopressin and motor activity in major depression. Biol Psychiatry. 1998;43:196–204
  45. Vanyukov MM, Moss HB, Plail JA, Blackson T, Mezzich AC, Tarter RE. Antisocial symptoms in preadolescent boys and in their parents: associations with cortisol. Psychiatry Res. 1993;46:9–17
  46. Virkkunen M. Urinary free cortisol secretion in habitually violent offenders. Acta Psychiatr Scand. 1985;72:40–44
  47. Watts AG. Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: A complexity beyond negative feedback. Frontiers Neuroendocrinol. 2005;26:109–130

PII: S0006-3223(06)00579-8

doi: 10.1016/j.biopsych.2006.03.081

Biological Psychiatry
Volume 60, Issue 8 , Pages 799-802 , 15 October 2006

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