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Effective Deep Brain Stimulation in Heroin Addiction: A Case Report with Complementary Intracranial Electroencephalogram
27 January 2012
Carlos-Eduardo Valencia-Alfonso, Judy Luigjes, Ruud Smolders, Michael X. Cohen, Nina Levar, Ali Mazaheri, Pepijn van den Munckhof, P. Richard Schuurman, Wim van den Brink, Damiaan Denys
Deep brain stimulation (DBS) treatment consists of permanently implanted electrodes that deliver electrical pulses to a target brain region. DBS of the nucleus accumbens shows encouraging results as t...
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Electrophysiological Assessment of Auditory Stimulus-Specific Plasticity in Schizophrenia
27 January 2012
Ryan P. Mears, Kevin M. Spencer
Background: Disrupted neuroplasticity may be an important aspect of the neural basis of schizophrenia. We used event-related brain potentials (ERPs) to assay neuroplasticity after auditory conditionin...
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Cortical Volume, Surface Area, and Thickness in Schizophrenia and Bipolar Disorder
27 January 2012
Lars M. Rimol, Ragnar Nesvåg, Don J. Hagler, Ørjan Bergmann, Christine Fennema-Notestine, Cecilie B. Hartberg, Unn K. Haukvik, Elisabeth Lange, Chris J. Pung, Andres Server, Ingrid Melle, Ole A. Andreassen, Ingrid Agartz, Anders M. Dale
Background: Magnetic resonance imaging studies have shown that structural brain abnormalities are present in both schizophrenia and bipolar disorder. Most previous studies have focused on brain tissue...
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Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease
27 January 2012
François Mouton-Liger, Claire Paquet, Julien Dumurgier, Pauline Lapalus, Françoise Gray, Jean-Louis Laplanche, Jacques Hugon, for the Groupe d'Investigation du Liquide Céphalorachidien Study Network
Background: The pathological hallmarks of Alzheimer's disease (AD) include accumulation of amyloid-β (Aß) peptide forming extracellular senile plaques, neurofibrillary tangles made of hyperphosphoryla...
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β-Arrestin2 Regulates Cannabinoid CB1 Receptor Signaling and Adaptation in a Central Nervous System Region–Dependent Manner
24 January 2012
Peter T. Nguyen, Cullen L. Schmid, Kirsten M. Raehal, Dana E. Selley, Laura M. Bohn, Laura J. Sim-Selley
Background: Cannabinoid CB1 receptors (CB1Rs) mediate the effects of ▵9-tetrahydrocannabinol (THC), the psychoactive component in marijuana. Repeated THC administration produces tolerance and dependen...
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